Shadow’s Exciting News, Part 2

Well, here we are five days into Week 3 of Shadow’s stem cell infusion; and the results are, well let’s just say A – mazing.  (I just wish I had before and after videos.)

If you missed the first post, you can read it here.

As you know, hubby and I – and the vet – went into this with cautious optimism and excitement over the possibilities for both Shadow and future pets. After all, this therapy IS still in the clinical trials stage.

I am beyond happy about, beyond excited about, and extremely grateful for the results we have been seeing already….

Shadow’s mobility has already improved about tenfold. After her little tumble in the backyard – about a week before the infusion – I figured the early signs we were seeing were simply the healing effects of the Gabapentin, CBD oil gel caps, and Tylenol 3 I’d been giving her. However, I had stopped the Tylenol 3 completely over that weekend prior to the infusion. And, due to my supplier’s lack of response to phone calls about the latest shipment, I also had to halve the dosage of the CBD oil gel caps. Yet, four days after the infusion hubby and I noticed that Shadow was indeed walking better and getting up and down the three steps better than before. And she continues to improve. Also, she isn’t struggling as much to get her back end up off the carpeted floors. In fact, she barely struggled at all this morning. And getting up off the linoleum floors is getting easier for her as well.

Shadow’s confidence in her own physical abilities is growing in subtle amounts…

She’s not “tiptoeing” across the kitchen floor – to keep her balance on the slippery surface – as much. In fact, this morning I noticed she walked normally from one side of the floor to the other with her head held high! And she didn’t have her slipper socks on, either!

Sometimes, in the morning mostly, Shadow will not eat her breakfast out of the bowl if I put it in the stand. The noise the bowls make when they move around seem to make her wary. (Yet it doesn’t seem to bother her at dinner time.) This morning, though, she stood at the bowl stand waiting for me to put her bowl in it and then ate all but four or five bites of it standing at the bowl. For now, I’ll attribute that bit of courage to the fact that she was hungry after yesterday’s reduced appetite status.

Shadow had been having normal poops as well; but between the stress of having been at the vet on Thursday morning, and then Ducky’s jealous streak on Friday night, they went back to being “yucky” again and still are today. I need to talk to the vet about that tomorrow. I have an idea of what’s causing it today, but I’ll keep it to myself for now. Hopefully it will go back to normal in a day or so.

Shadow’s Exciting News

Shadow is participating in a clinical trial!

Let me begin by telling you that back in May – while I was still at my brother’s home – one of our two vets at Sunrise Animal Hospital called to talk to me about an exciting new treatment for canine joint disease that is still in the clinical testing phase.

Dr. Simpson told me that this new therapy (HUC-DT) uses the stem cells from human umbilical cords; and that he felt Shadow would be a good candidate for the treatment. A quick note here for those of you who, like me, have heard of stem cell therapy but aren’t familiar with how it works: stem cells are the cells present in all our bodies that are there to help heal and rebuild tissues. As we age, we have fewer stem cells but their healing and regenerative effect remains intact if needed.*

When we give a pet human stem cells, the stem cells migrate to the areas of pain and inflammation by following the body’s natural cues, and anchor themselves within the tissues, and begin stimulating the dog’s natural stem cell population to fight inflammation and rebuild tissues.”

The old method of using stem cell therapies in pets was mostly limited to what is known as mesenchymal stem cell transplants (MST). This method required not one surgery, but two surgeries. The first surgery involved anesthetizing the pet and harvesting a large amount of fat cells. Those cells were then sent to a lab where the stem cells were extracted, given various chemical treatments to “boost their vitality”, and shipped back to the veterinarian. Then the pet had to undergo anesthesia a second time to have the treated stem cells implanted. Such a process is not only costly and time-consuming, but also puts the pet at risk of potential dangerous anesthesia side effects twice. Not really a viable option for the older pet.*

The process Dr. Simpson used for Shadow (and other patients, including his own dog) does not involve anesthesia, or any chemicals to boost the stem cells’ viability. Dr. Simpson explains the whole procedure in the video clip below. (We had a slight technical issue at the very beginning which cut off some of Dr. Simpson’s introduction, but that’s okay. You can still get the idea.)

We also took videos of Shadow walking, and then jogging, down the long hallway outside the treatment area so we can document the results of the therapy. And we took some other photos as well.

Hubby and I are both cautiously optimistic about the eventual positive effects on Shadow’s overall quality of life; and excited by the all-natural and safety aspects of the treatment.

On average, results can be expected between four and six weeks following the treatment; but many of Dr. Simpson’s other patients started presenting subtle changes in behavior within two weeks that indicated the treatment was already helping them. I will follow up with more blog posts about how the treatment works for Shadow.

Lastly, I want to give credit where it’s due: All of the “technical” wording that’s either followed by an asterisk (*) or set within quotation marks is either paraphrased or directly quoted from Dr. Simpson’s white paper that he wrote about the HUC-DT treatment. He provided me with a copy for information purposes, and so I could write this post. Please feel free to ask questions in the comments. If I don’t know the answers, I’ll ask Dr. Simpson.

I Love Our Vet!

Yes, I know I’ve said before that I love our vet, but I’m saying it again. I Love Our Vet! 

Not just because he has always taken good care of our pets; but also because he has always been honest and forthright on all fronts.

Not just because he let me do my externship (for my vet assistant course) at his hospital; but also because he has always been there for us (just a call or text away) from the time Ducky started presenting IBD symptoms, throughout Callie’s lymphoma journey, and every day since.

You might recall in my last post, Happy 13th Birthday, Shadow, I mentioned that thanks to her little sister Shadow had taken a tumble a couple of weeks ago. Thanks to the hemp oil gel caps and elixir drops and daily walks on the treadmill, the tumble didn’t seem to bother her then.

Still, over the last 10 days, she seemed to be struggling more to stand up and stay up. And she hasn’t been eating as well or as much, plus her reflux seems to bother her more often again. So, I brought Shadow back to Dr. Steve for his professional opinion on Tuesday morning. I mentioned that with her increased struggling of late I was worried that maybe she was in more pain than she let on. He put my mind at ease. “No injury. Just her arthritis flaring a little.”

I sent Doc a video of Shadow walking on the treadmill yesterday morning; and when he called in the afternoon with the lab results he commented on the video. “She looks great. She walks like an older dog with some arthritis. Her range of motion isn’t what it used to be, but it’s pretty good for an old lady.” As for the blood work and urinalysis, everything is close to or at normal levels, which means the Denamarin is working. We talked about some other minor concerns; but all’s well. The Gabapentin, hemp oil, and treadmill – and outdoor playtime – is keeping her arthritis manageable. So, we’re sticking with what works.

Now it’s time to get back to working on my final exam. It’s due back to my program manager on the 30th, so I probably won’t publish another post before Halloween.

Happy Thankful Thursday!!!

TGIF 

It has been a busy week around here and I’m glad it’s about over.

As I started writing the draft of this post on Tuesday morning, my sweet, loving Golden Shadow was in a kennel at the vet’s office. 

She was awaiting her turn with Dr. Steve, and for me to return for her.

Last Friday, we did a re-check of her liver enzyme levels after 30 days on the Denosyl.

The Denosyl did not work. Those enzyme levels which were elevated 36 days ago were even more elevated this time. And other levels were also elevated that had been in the normal range. 

So, on Tuesday afternoon – at the vet’s recommendation – we did an ultrasound on her liver and abdominal region.  

Turns out she has some old-age abscesses in her liver which we will be treating with Ampicillin and Denamarin for a month. She also has a small nodule in her spleen that does NOT appear to have any worrisome characteristics. But just to be on the safe side we will do another ultrasound in a month to check on it.

Meanwhile, Ducky had the first of two CIV (Canine Influenza Virus) vaccinations on Tuesday morning as well. It doesn’t reach its full efficacy until two weeks after the second “shot”. So, our little girl will not be going back to daycare until some time in July. I’m not taking any unnecessary chances of her being infected and passing it on to Shadow. Especially now. She seems happy enough to stay home…

So today – as always – I am thankful that we have a great relationship with a wonderful vet. And, by the way, his hospital/practice is now accredited by the #AAHA.

I’m also thankful for – among so many other blessings – our wonderful pet-loving community. I honestly don’t know what I’d do without y’all!  (I meant to join the Thankful Thursday blog hop but didn’t have time.)

Taking A Break

The girls and I are taking a fresh-air break…


We’ve been inside most of the morning – eating breakfast, having to listen to the news and the dog-daddy cussing at the TV, and me working on my test answers for Stage 2 of my Vet Assistant course.

Oh! I didn’t tell you yet! I got a 95% on my Stage 1 exam. Proud of myself? Hell Yes!!

Anyway, I have more work to do this afternoon on my upcoming test, so decided to get some fresh air first. And Ducky’s been in brat mode this morning. Hopefully the fresh air will settle her down a bit.

It’s chilly out here, like Spring should be! Temps are in the high 50s/low 60s, there’s a strong breeze (more like a “wind”), and the sun is playing peek-a-boo with the puffy, white clouds and gorgeous blue sky.


To think that this time last week I was wearing shorts and short-sleeve t-shirts and spending late afternoons in the air-conditioned house. Crazy weather!

Tomorrow is Shadow’s re-check appointment with Dr. Steve. Hopefully he’ll say the toe sprain has healed enough to be able to lift her playtime restrictions. We both miss our favorite game. And Ducky will be at daycare for a few hours.

We hope y’all will have a great day!!